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https://hdl.handle.net/20.500.11851/884
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DC Field | Value | Language |
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dc.contributor.author | Akın, Dilara Fatma | - |
dc.contributor.author | Özkan, Didem T. | - |
dc.contributor.author | Kürekci, Emin | - |
dc.contributor.author | Akar, Nejat | - |
dc.date.accessioned | 2019-03-29T07:37:02Z | |
dc.date.available | 2019-03-29T07:37:02Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Akin, D. F., Özkan, D. T., Kürekçi, E., & Akar, N. (2018). Screening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia. The Egyptian Journal of Haematology, 43(2), 45. | en_US |
dc.identifier.uri | http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2018;volume=43;issue=2;spage=45;epage=48;aulast=Akin | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/884 | - |
dc.description.abstract | Background CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in downregulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine (G>A) transition in the CD95 promoter region (position −1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease CD95 expression. The purpose of this study is to examine a genetic polymorphism in the core promoter region of CD95 and to evaluate association between its frequency and clinical findings. Patients and methods G-1377A in the CD95 promoter region was genotyped by polymerase chain reaction and restriction endonuclease analysis finally were sequenced by Sanger Sequecing. Results Among 146 patients, CD95 G-1377A (rs2234767) single nucleotide polymorphism carriers frequencies have been identified as 25% (n=37) GA and AA 4% (n=6). This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. Conclusion This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.relation.ispartof | The Egyptian Journal of Haematology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | CD95 polymorphism | en_US |
dc.subject | acute myeloblastic leukemia | en_US |
dc.subject | acute lymphoblastic leukemia | en_US |
dc.title | Screening of Single Nucleotide Polymorphism in Cd95 (apo-1/Fas) Promoter Region (g-1377a) in Children With Acute Leukemia | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Internal Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 45 | en_US |
dc.identifier.endpage | 48 | en_US |
dc.identifier.wos | WOS:000441639800001 | en_US |
dc.institutionauthor | Akar, Nejat | - |
dc.identifier.doi | 10.4103/ejh.ejh_55_17 | - |
dc.identifier.doi | 10.4103/ejh.ejh_55_17 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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