Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8343
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dc.contributor.authorSert, Gökhan-
dc.contributor.authorKüçükgüven, Arda-
dc.contributor.authorZırh, Elham Bahador-
dc.contributor.authorDemirtaş, Tuğrul T.-
dc.contributor.authorÇakar, Ayşe Nur-
dc.contributor.authorGümüşderelioğlu, Menemse-
dc.contributor.authorÇalış, Mert-
dc.date.accessioned2022-01-15T13:02:35Z-
dc.date.available2022-01-15T13:02:35Z-
dc.date.issued2021-
dc.identifier.issn0196-8092-
dc.identifier.issn1096-9101-
dc.identifier.urihttps://doi.org/10.1002/lsm.23457-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8343-
dc.description.abstractObjectives Unpredictability with the final volume and viability of the graft are the major concerns in fat grafting. An experimental study was conducted to increase graft retention using photobiomodulation (PBM) with polychromatic light in near-infrared region (600-1200 nm) by utilizing its stimulatory effects on angiogenesis, neovascularization, adipocyte viability, and anti-inflammatory properties. Methods A total of 24 rats were divided into four groups (n = 6) according to the applied polychromatic light protocol to the recipient site (none, before fat transfer, after fat transfer, and combined). In all groups, inguinal fat pad was excised, measured for volume and weight, and transferred to the dorsum of the rat. At the end of the experiment, fat grafts were harvested from the recipient site for volume and weight measurements, histological, and immunohistochemical evaluation. Results Intergroup comparison revealed that fat graft retention regarding weight and volume, was significantly superior in Group IV (p = 0.049 and p = 0.043, respectively), which polychromatic light was applied both before and after transfer of the graft. Hematoxylin-eosin and Masson's trichrome stained sections showed absence of necrosis, fibrosis, inflammation, cyst formation, and increased vascularization of both inner and outer zones of the grafts in Group IV. Also, immunohistochemical staining scores for perilipin (indicator for adipocyte viability), CD31 and VEGF (indicators for angiogenesis and neovascularization) were significantly higher (p < 0.001). Ki67 scores were significantly lower in this group because of anti-inflammatory environment (p < 0.001). Conclusions Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation.en_US
dc.description.sponsorshipHacettepe University Scientific Research FoundationHacettepe University [THD-2019-18219]en_US
dc.description.sponsorshipThe authors acknowledge the support gained from the Hacettepe University Scientific Research Foundation (Grant No: THD-2019-18219) for this study.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLasers In Surgery and Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfat graften_US
dc.subjectphotobiomodulationen_US
dc.subjectpolychromatic lighten_US
dc.subjectLevel Laser Therapyen_US
dc.subjectEndothelial-Cell Proliferationen_US
dc.subjectWhite Adipose-Tissueen_US
dc.subjectStem-Cellsen_US
dc.subjectIrradiationen_US
dc.subjectVegfen_US
dc.subjectPromotesen_US
dc.subjectGeneen_US
dc.subjectAngiogenesisen_US
dc.subjectExpressionen_US
dc.titlePhotobiomodulation With Polychromatic Light (600-1200 Nm) Improves Fat Graft Survival by Increasing Adipocyte Viability, Neovascularization, and Reducing Inflammation in a Rat Modelen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.authoridDemirtas, Tugrul Tolga / 0000-0002-7806-6195-
dc.identifier.wosWOS:000677832300001en_US
dc.identifier.scopus2-s2.0-85110948063en_US
dc.institutionauthorÇakar, Ayşe Nur-
dc.institutionauthorBahador Zırh, Elham-
dc.identifier.pmid34289510en_US
dc.identifier.doi10.1002/lsm.23457-
dc.authorwosidDemirtas, Tugrul Tolga / C-9785-2015-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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