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https://hdl.handle.net/20.500.11851/8308
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DC Field | Value | Language |
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dc.contributor.author | Örgül, Gökçen | - |
dc.contributor.author | Dalva, Klara | - |
dc.contributor.author | Dalva-Aydemir, Sevim | - |
dc.contributor.author | Alnıaçık, Ridvan Goksel | - |
dc.contributor.author | Dönmez, Hanife Güler | - |
dc.contributor.author | Çakar, Ayşe Nur | - |
dc.contributor.author | Beksaç, Meral | - |
dc.date.accessioned | 2022-01-15T13:02:29Z | - |
dc.date.available | 2022-01-15T13:02:29Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0165-0378 | - |
dc.identifier.issn | 1872-7603 | - |
dc.identifier.uri | https://doi.org/10.1016/j.jri.2021.103425 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/8308 | - |
dc.description.abstract | Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood. We aimed to demonstrate the association of maternal KIR-fetal KIR ligand genotype combinations with immunological/metabolic risk factor associated placenta-related obstetric complications. This study consisted of three groups of pregnant women: 1) Miscarriage group (n = 30), 2) Complicated Pregnancy (CP) group (n = 30), and 3) Control group (n = 30). The observed maternal genotype frequencies of all inhibitory and activating KIRs were similar in all groups (p > 0.05). However, inhibitory 2DL3 was quite frequent in the miscarriage group (p = 0.052). There was no difference between groups in terms of centromeric and telomeric maternal haplotypes (p > 0.05). The fetal group 1 HLA-C genotype was frequently detected in the miscarriage and CP groups with rates of 83.3 % and 93.3 % respectively, while the observed frequency was 70 % in the control group. The fetal group 2 HLA-C genotype was the same in all groups. The results demonstrated significantly less fetal group 2 HLA-C homozygosity in the CP groups when compared to the control group (p = 0.020). The fetal HLA-Bw4 genotype was detected more frequently in the miscarriage and CP groups (p = 0.028 and p = 0.001, respectively). The inhibitory KIR/KIR ligand genotype combinations of 2DL3-C1 and 3DL1-Bw4 were more frequent in the miscarriage and CP groups (p = 0.045 and p = 0.002, respectively). Enhanced NK cell inhibition may be one of the mechanisms underlying placenta-related obstetric complications. | en_US |
dc.description.sponsorship | Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [THD-2017-14660] | en_US |
dc.description.sponsorship | This study was funded by Hacettepe University Scientific Research Projects Coordination Unit, Project number: THD-2017-14660. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.relation.ispartof | Journal of Reproductive Immunology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Natural killer cell | en_US |
dc.subject | Killer cell immunoglobulin like receptor | en_US |
dc.subject | Major histocompatibility complex Class-I antigen | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Placental inflammation | en_US |
dc.subject | Obstetric complication | en_US |
dc.subject | Miscarriage | en_US |
dc.subject | Hla-C | en_US |
dc.subject | Trophoblast Migration | en_US |
dc.subject | Angiogenesis | en_US |
dc.subject | Preeclampsia | en_US |
dc.subject | Evolution | en_US |
dc.subject | Genes | en_US |
dc.title | Significance of Inhibitory Maternal Killer-Cell Immunoglobulin-Like Receptor (kir) and Fetal Kir Ligand Genotype Combinations in Placenta Related Obstetric Complications | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Basic Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 148 | en_US |
dc.authorid | Orgul, Gokcen / 0000-0003-0578-4230 | - |
dc.identifier.wos | WOS:000708239900008 | en_US |
dc.identifier.scopus | 2-s2.0-85116039673 | en_US |
dc.institutionauthor | Çakar, Ayşe Nur | - |
dc.identifier.pmid | 34607283 | en_US |
dc.identifier.doi | 10.1016/j.jri.2021.103425 | - |
dc.authorwosid | Orgul, Gokcen / M-3850-2019 | - |
dc.authorwosid | AYDEMIR, Sevim DALVA / AAO-7800-2020 | - |
dc.authorscopusid | 55441310800 | - |
dc.authorscopusid | 6601955440 | - |
dc.authorscopusid | 56534178800 | - |
dc.authorscopusid | 57278557800 | - |
dc.authorscopusid | 56736124600 | - |
dc.authorscopusid | 35612346700 | - |
dc.authorscopusid | 56924887200 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 03.14. Department of Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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