Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7579
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dc.contributor.authorÜnver, Hakkı Özgür-
dc.date.accessioned2021-09-11T15:57:59Z-
dc.date.available2021-09-11T15:57:59Z-
dc.date.issued2011en_US
dc.identifier.issn1094-6977-
dc.identifier.issn1558-2442-
dc.identifier.urihttps://doi.org/10.1109/TSMCC.2011.2107552-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7579-
dc.description.abstractAs many biopharma companies fill their drug-discovery pipeline with new blockbuster candidates every year, the integration techniques employed become more critical. In the biopharma industry, high throughput screening (HTS) is an essential function to deliver new drugs rapidly and cost effectively. This interdisciplinary function requires not only understanding of the biology and biochemistry underlying the therapeutic target but involves engineering functions, such as automation, robotics, detection technologies, high-volume data acquisition, and analysis as well. This paper discusses a six-year long research and development (R&D) effort in pursuit of developing system architectures that makes HTS systems more flexible and reconfigurable. Fromthe capital-intensive pharmaceutical laboratories to booming biotech startups driven by advances in human genomics, changing architectural paradigms in screening automation are reviewed. Recently, flexibility and reconfigurability of systems to achieve maximum utilization has emerged as the dominant requirement from a systems perspective as reuse of expensive instruments and equipment is an essential component of cost-effectiveness in drug discovery. In order to enable reconfigurability of systems, we present our modular and object-oriented control-system framework and software-design patterns adopted into our control architecture. Embodiment of these patterns in our control architecture added value to functions of various stakeholders of products from R&D engineers, marketing/sales, to field service and users. Further, we discuss the requirements, design, and implementation of these unique patterns, which effectively balances reusability, flexibility, ease of use, and throughput in integrated-system platforms that we have developed. The techniques and models that are presented in this paper will improve architectural flexibility of HTS systems, thereby helping automation experts, scientists, chemists, and other levels of users in the field to make the most out of their systems.en_US
dc.language.isoenen_US
dc.publisherIEEE-Inst Electrical Electronics Engineers Incen_US
dc.relation.ispartofIEEE Transactions On Systems Man And Cybernetics Part C-Applications And Reviewsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh throughput screening (HTS)en_US
dc.subjectlaboratory automation systemsen_US
dc.subjectobject-oriented design and developmenten_US
dc.subjectreconfigurable automationen_US
dc.subjectsoftware patternsen_US
dc.titleSystem Architectures Enabling Reconfigurable Laboratory-Automation Systemsen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Computer Engineeringen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümütr_TR
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume41en_US
dc.identifier.issue6en_US
dc.identifier.startpage909en_US
dc.identifier.endpage922en_US
dc.identifier.wosWOS:000296019400011en_US
dc.identifier.scopus2-s2.0-80054807131en_US
dc.institutionauthorÜnver, Hakkı Özgür-
dc.identifier.doi10.1109/TSMCC.2011.2107552-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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