Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/7546
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Başaran, Özcan | - |
dc.contributor.author | Doğan, Volkan | - |
dc.contributor.author | Beton, Osman | - |
dc.contributor.author | Tekinalp, Mehmet | - |
dc.contributor.author | Aykan, Ahmet Çağrı | - |
dc.contributor.author | Kalaycıoğlu, Ezgi | - |
dc.contributor.author | Başaran, Nesrin Filiz | - |
dc.date.accessioned | 2021-09-11T15:57:44Z | - |
dc.date.available | 2021-09-11T15:57:44Z | - |
dc.date.issued | 2016 | en_US |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://doi.org/10.1097/MD.0000000000004672 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/7546 | - |
dc.description.abstract | This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of <3, whereas that of OT were creatinine clearance <50mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of 3.The suboptimal use of NOACs is common because of physicians' poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.ispartof | Medicine | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | anticoagulation | en_US |
dc.subject | atrial fibrillation | en_US |
dc.subject | off-label use | en_US |
dc.subject | over-treatment | en_US |
dc.subject | stroke | en_US |
dc.subject | undertreatment | en_US |
dc.title | Suboptimal Use of Non-Vitamin K Antagonist Oral Anticoagulants: Results From the Ramses Study | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Internal Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 95 | en_US |
dc.identifier.issue | 35 | en_US |
dc.authorid | 0000-0003-0230-6575 | - |
dc.authorid | 0000-0001-5793-7978 | - |
dc.authorid | 0000-0003-2030-3810 | - |
dc.authorid | 0000-0002-1331-5365 | - |
dc.authorid | 0000-0002-7623-5928 | - |
dc.authorid | 0000-0003-1058-7194 | - |
dc.identifier.wos | WOS:000384041400052 | en_US |
dc.institutionauthor | Çelebi, Aksüyek Savaş | - |
dc.identifier.pmid | 27583892 | en_US |
dc.identifier.doi | 10.1097/MD.0000000000004672 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
CORE Recommender
SCOPUSTM
Citations
22
checked on Dec 21, 2024
WEB OF SCIENCETM
Citations
31
checked on Dec 21, 2024
Page view(s)
76
checked on Dec 23, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.