Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7324
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKabalak, Pınar Akın-
dc.contributor.authorÇiledağ, Aydın-
dc.contributor.authorDemir, Nalan-
dc.contributor.authorÇelik, Gökhan-
dc.contributor.authorYüksel, Cabir-
dc.contributor.authorKoycu, Gözde-
dc.contributor.authorSavaş, İsmail-
dc.date.accessioned2021-09-11T15:56:26Z-
dc.date.available2021-09-11T15:56:26Z-
dc.date.issued2015en_US
dc.identifier.issn0494-1373-
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/184609-
dc.identifier.urihttps://doi.org/10.5578/tt.9015-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7324-
dc.description.abstractIntroduction: Vascular endothelial growth factor (VEGF) and Angiopoietin-2 (Ang-2) are major angiogenic mediators in neovascularization process. In current literature both biomarkers are discussed separately and only for non-small cell lung cancer (NSCLC). So in this study we aimed to examine them together for both cell types NSCLC and small cell lung cancer (SCLC). Patients and Methods: 100 patients with lung cancer were enrolled to this single center study. 87 of patients were diagnosed with NSCLC including 28 adenocarcinomas and 59 squamous cell cancers and 13 were SCLC. Results were compared with 30 healthy volunteers. Pre-treatment serum VEGF and Ang-2 levels were measured by using ELISA method. Results: While serum Ang-2 levels were higher in patients than healthy controls (23395 pg/mL vs. 4025 pg/mL, p< 0.001), VEGF levels didn't differ (2308 pg/mL vs. 2433 pg/mL, p> 0.05). There was no difference between cases with SCLC and NSCLC in terms of Ang-2. But serum VEGF values were significantly lower in SCLC than NSCLC and control groups. None of these mediators were correlated with cell type, tumor size, TNM staging, performance status and operability. VEGF levels were higher in patients with chronic obstructive pulmonary disease (COPD), but it was not significant. Three cut of values were determined according to sensitivity and specificity by using youden index. They were 8515.73 pg/mL (sensitivity 78%, specificity 76%), 7097 pg/mL (sensitivity 80%, specificity 70%) and 11063.48 pg/mL (sensitivity 76%, specificity 70%). Patients with SCLC had shorter survival time above cut-off values (p> 0.05). VEGF and Ang-2 showed a weak positive correlation (p= 0.1 and r= 0.638). Conclusion: In conclusion, serum VEGF wasn't useful to predict lung cancer, prognosis or cell type. Albeit Ang-2 was higher in patients with lung cancer without any effect on survival. Due to the heterogeneity of the studies done with serum measurement Ang-2 on tumor tissue should be more meaningful.en_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis And Thoraxen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectlung canceren_US
dc.subjectserum biomarkersen_US
dc.subjectsurvivalen_US
dc.titlePrognostic Significance of Serum Vascular Endothelial Growth Factor and Angiopoietin-2 in Patients With Lung Canceren_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume63en_US
dc.identifier.issue2en_US
dc.identifier.startpage71en_US
dc.identifier.endpage77en_US
dc.authorid0000-0003-0869-8979-
dc.authorid0000-0002-3480-4803-
dc.authorid0000-0003-1645-7761-
dc.identifier.wosWOS:000421349200001en_US
dc.identifier.scopus2-s2.0-84953790511en_US
dc.institutionauthorTaner, Abbas-
dc.institutionauthorNumano?lu, Numan-
dc.identifier.pmid26167963en_US
dc.identifier.doi10.5578/tt.9015-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
dc.identifier.trdizinid184609en_US
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

7
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

8
checked on Dec 21, 2024

Page view(s)

56
checked on Dec 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.