Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7317
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dc.contributor.authorBayrak, Ece-
dc.contributor.authorÖzcan, Burak-
dc.contributor.authorErişken, Cevat-
dc.date.accessioned2021-09-11T15:56:24Z-
dc.date.available2021-09-11T15:56:24Z-
dc.date.issued2017en_US
dc.identifier.issn0334-6447-
dc.identifier.issn2191-0340-
dc.identifier.urihttps://doi.org/10.1515/polyeng-2016-0017-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7317-
dc.description.abstractThe process of electrospinning is utilized with different approaches including conventional electrospinning, extrusion electrospinning, and electroblowing to form nanofibrous meshes and composites. Here, we report on the quality and properties of spatially graded polycaprolactone (PCL) and nano-hydroxyapatite (nHA) composite meshes fabricated with multiple-spinneret electrospinning. The composite meshes were characterized in terms of the amount of spatially allocated nHA concentration across the mesh, fiber diameter, porosity, pore size, and hydrophilicity of meshes. Results show that linearly and continuously varying nHA concentration distribution, i.e. graded structure, can be accomplished across the mesh thickness using multiple-spinneret electrospinning, which is in accordance with the change of mineral concentration observed in native tendon-bone interface. Furthermore, incorporation of nanoparticles into nanofibers led to increased fiber diameter as depicted by a shift in fiber diameter distribution, a significant increase in mean fiber diameter from 361 +/- 9 nm to 459 +/- 21 nm, and an increase in contact angle from 120.01 +/- 2.77 degrees to 115.24 +/- 1.17 degrees. These findings suggest that the composite meshes formed in this study could serve as model systems to be used as scaffolds in tendon-bone tissue engineering application in particular, and for other tissue-tissue interfaces in a broader context.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115C001]en_US
dc.description.sponsorshipWe are grateful to Dr. Dilhan Kalyon for providing the facilities of Highly Filled Materials Institute, Hoboken, NJ, for thermogravimetric characterizations. We thank Dr. Mehmet Mutlu, Dr. Fatih Buyukserin, and Ms. Sevde Altuntas, TOBB University of Economics and Technology, Turkey, for their technical support. We also thank Ms. Gonca Bilge, for her help with contact angle measurements. The authors gratefully acknowledge funding support from the Scientific and Technological Research Council of Turkey (Project no. 115C001).en_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Polymer Engineeringen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgradingen_US
dc.subjecthydroxyapatiteen_US
dc.subjectinterfaceen_US
dc.subjectmultiple-spinneret electrospinningen_US
dc.subjectpolycaprolactoneen_US
dc.subjectregenerationen_US
dc.subjecttissue engineeringen_US
dc.titleProcessing of Polycaprolactone and Hydroxyapatite To Fabricate Graded Electrospun Composites for Tendon-Bone Interface Regenerationen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume37en_US
dc.identifier.issue1en_US
dc.identifier.startpage99en_US
dc.identifier.endpage106en_US
dc.authorid0000-0002-3460-1942-
dc.identifier.wosWOS:000392301400010en_US
dc.identifier.scopus2-s2.0-85112656153en_US
dc.institutionauthorErişken, Cevat-
dc.identifier.doi10.1515/polyeng-2016-0017-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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