Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7277
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dc.contributor.authorÇalış, Mert-
dc.contributor.authorIrmak, Gülseren-
dc.contributor.authorDemirtaş, Tuğrul Tolga-
dc.contributor.authorKara, Murat-
dc.contributor.authorÜstün, Galip Gencay-
dc.contributor.authorGümüşderelioğlu, Menemse-
dc.contributor.authorÖzgür, Figen-
dc.date.accessioned2021-09-11T15:56:13Z-
dc.date.available2021-09-11T15:56:13Z-
dc.date.issued2022en_US
dc.date.issued2022-
dc.identifier.issn0268-8921-
dc.identifier.issn1435-604X-
dc.identifier.urihttps://doi.org/10.1007/s10103-021-03308-y-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7277-
dc.description.abstractReconstruction of bone defects is still a significant challenge. The aim of this study was to evaluate the effect of application of photobiomodulation (PBM) to enhance in vivo bone regeneration and osteogenic differentiation potential of adipose-derived stem cells (ADSCs) encapsulated in methacrylated gelatin (GEL-MA) hydrogels. Thirty-six Sprague-Dawley rats were randomly separated into 3 experimental groups (n = 12 each). The groups were control/blank defect (I), GEL-MA hydrogel (II), and ADSC-loaded GEL-MA (GEL-MA+ADSC) hydrogel (III). Biparietal critical sized bone defects (6 mm in size) are created in each animal. Half of the animals from each group (n = 6 each) were randomly selected for PBM application using polychromatic light in the near infrared region, 600-1200 nm. PBM was administered from 10 cm distance cranially in 48 h interval. The calvaria were harvested at the 20th week, and macroscopic, microtomographic, and histologic evaluation were performed for further analysis. Microtomographic evaluation demonstrated the highest result for mineralized matrix formation (MMF) in group III. PBM receiving samples of group III showed mean MMF of 79.93 +/- 3.41%, whereas the non-PBM receiving samples revealed mean MMF of 60.62 +/- 6.34 % (p=0.002). In terms of histologic evaluation of bone defect repair, the higher scores were obtained in the groups II and III when compared to the control group (2.0 for both PBM receiving and non-receiving specimens; p<0.001). ADSC-loaded microwave-induced GEL-MA hydrogels and periodic application of photobiomodulation with polychromatic light appear to have beneficial effect on bone regeneration and can stimulate ADSCs for osteogenic differentiation.en_US
dc.description.sponsorshipHacettepe University Scientific Research FoundationHacettepe University [THD-2017-14465]en_US
dc.description.sponsorshipThis work was supported from the Hacettepe University Scientific Research Foundation (Grant No: THD-2017-14465).en_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofLasers In Medical Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolychromatic lighten_US
dc.subjectMicrowave-induced methacrylated gelatinen_US
dc.subjectAdipose-derived stem cellsen_US
dc.subjectCalvarial defecten_US
dc.subjectBone regenerationen_US
dc.titlePhotobiomodulation Combined With Adipose-Derived Stem Cells Encapsulated in Methacrylated Gelatin Hydrogels Enhances in Vivo Bone Regenerationen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.authorid0000-0002-8170-7459-
dc.identifier.wosWOS:000638833100001en_US
dc.identifier.scopus2-s2.0-85104242372en_US
dc.institutionauthorTürkkanı, Ayten-
dc.institutionauthorÇakar, Ayşe Nur-
dc.identifier.pmid33839962en_US
dc.identifier.doi10.1007/s10103-021-03308-y-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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