Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7046
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dc.contributor.authorÇetin, Barbaros-
dc.contributor.authorÖzer, Mehmet Bülent-
dc.contributor.authorSolmaz, Mehmet Ertugrul-
dc.date.accessioned2021-09-11T15:45:08Z-
dc.date.available2021-09-11T15:45:08Z-
dc.date.issued2014en_US
dc.identifier.citationCetin, B., Özer, M. B., & Solmaz, M. E. (2014). Microfluidic bio-particle manipulation for biotechnology. Biochemical engineering journal, 92, 63-82.en_US
dc.identifier.issn1369-703X-
dc.identifier.issn1873-295X-
dc.identifier.urihttps://doi.org/10.1016/j.bej.2014.07.013-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7046-
dc.description.abstractMicrofluidics and lab-on-a-chip technology offers unique advantages for the next generation devices for diagnostic therapeutic applications. For chemical, biological and biomedical analysis in microfluidic systems, there are some fundamental operations such as separation, focusing, filtering, concentration, trapping, detection, sorting, counting, washing, lysis of bio-particles, and PCR-like reactions. The combination of these operations led to the complete analysis systems for specific applications. Manipulation of the bio-particles is the key ingredient for these applications. Therefore, microfluidic bio-particle manipulation has attracted a significant attention from the academic community. Considering the size of the bio-particles and the throughput of the practical applications, manipulation of the bio-particles is a challenging problem. Different techniques are available for the manipulation of bio-particles in microfluidic systems. In this review, some of the techniques for the manipulation of bio-particles; namely hydrodynamic based, electrokinetic-based, acoustic-based, magnetic-based and optical-based methods have been discussed. The comparison of different techniques and the recent applications regarding the microfluidic bio-particle manipulation for different biotechnology applications are presented. Finally, challenges and the future research directions for microfluidic bio-particle manipulation are addressed. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK 2232 programTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113C001]; Katip Celebi University Scientific Research ProjectIzmir Katip Celebi University [2014-1-MUH-23]en_US
dc.description.sponsorshipDr. Cetin would like to thank Ms. Soheila Zeinali for her assistance in the preparation of 3D drawings, and Dr. Sinan Filiz for the fabrication and preparation of the SEM images of the mold and channels fabricated by micro-machining. Dr. Solmaz would like to acknowledge TUBITAK 2232 program (113C001) and Katip Celebi University Scientific Research Project (2014-1-MUH-23) for the financial support.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiochemical Engineering Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomedicalen_US
dc.subjectBioprocess designen_US
dc.subjectBioseparationsen_US
dc.subjectFluid Mechanicsen_US
dc.subjectMicrofluidicsen_US
dc.subjectBio-particle manipulationen_US
dc.titleMicrofluidic Bio-Particle Manipulation for Biotechnologyen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume92en_US
dc.identifier.startpage63en_US
dc.identifier.endpage82en_US
dc.authorid0000-0001-9824-4000-
dc.authorid0000-0001-9824-4000-
dc.authorid0000-0002-0380-5125-
dc.identifier.wosWOS:000344825400011en_US
dc.identifier.scopus2-s2.0-84908381544en_US
dc.institutionauthorÖzer, Mehmet Bülent-
dc.identifier.doi10.1016/j.bej.2014.07.013-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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