Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6994
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dc.contributor.authorBeksaç, Mehmet Sinan-
dc.contributor.authorTanacan, Atakan-
dc.contributor.authorÖzten, Gonca-
dc.contributor.authorÇakar, Ayşe Nur-
dc.date.accessioned2021-09-11T15:44:45Z-
dc.date.available2021-09-11T15:44:45Z-
dc.date.issued2022-
dc.identifier.issn1476-7058-
dc.identifier.issn1476-4954-
dc.identifier.urihttps://doi.org/10.1080/14767058.2020.1760834-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6994-
dc.description.abstractObjective: We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation. Materials and methods: This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation. Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53). Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups. Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas. Results: Pregnancy outcomes were significantly better in the present pregnancy than in previous pregnancies. A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all). A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all). Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas. Conclusion: Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLow-molecular-weight heparinen_US
dc.subjectperinatal morbidity and mortalityen_US
dc.subjectpregnancyen_US
dc.titleLow-Dose Low-Molecular Heparin Prophylaxis Against Obstetrical Complications in Pregnancies With Metabolic and Immunological Disorder-Associated Placental Inflammationen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.authorid0000-0001-6362-787X-
dc.identifier.wosWOS:000532145400001en_US
dc.identifier.scopus2-s2.0-85084264850en_US
dc.institutionauthorÇakar, Ayşe Nur-
dc.identifier.pmid32354247en_US
dc.identifier.doi10.1080/14767058.2020.1760834-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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