Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6901
Full metadata record
DC FieldValueLanguage
dc.contributor.authorShatla, Hamed M.-
dc.contributor.authorTomoum, Hoda Y.-
dc.contributor.authorElsayed, Solaf M.-
dc.contributor.authorAly, Rasha H.-
dc.contributor.authorShatla, Rania H.-
dc.contributor.authorİsmail, Mona A.-
dc.contributor.authorNejat, Akar M.-
dc.date.accessioned2021-09-11T15:44:10Z-
dc.date.available2021-09-11T15:44:10Z-
dc.date.issued2012en_US
dc.identifier.issn0887-8994-
dc.identifier.issn1873-5150-
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2012.05.008-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6901-
dc.description.abstractPediatric stroke is relatively uncommon, with often subtle clinical presentations. Numerous predisposing risk factors can be both inherited and acquired, including cardiac disease, vascular abnormalities, infectious diseases, collagen tissue diseases, inborn errors of metabolism, anticardiolipin antibody, lupus anticoagulant, deficiencies of protein C, protein S, antithrombin, or plasminogen, and prothrombotic mutations. We explored risk factors, clinical features, and neuroimaging among Egyptian children with ischemic stroke, and estimated the prevalence of inherited thrombophilia. We included 20 children with ischemic stroke, recruited from the Pediatric Neurology Outpatient Clinic (Ain Shams University). Basic clinical evaluations for stroke and genotyping for factor V 1691 G-A (factor V Leiden), prothrombin 20210 G-A mutations, and methylenetetrahydrofolate reductase 677 C-T polymorphisms were performed using real-time polymerase chain reaction, with fluorescent melting curve detection analysis. Ten patients (50%) manifested methylenetetrahydrofolate reductase polymorphisms (six homozygotes and four heterozygotes). Heterozygous factor V Leiden was present in five (25%), whereas prothrombin mutation was present in only one (5%). Five patients (25%) manifested combined prothrombotic abnormalities. Thirteen demonstrated evidence of inherited thrombophilic disorder; 25% manifested more than one mutation. For appropriate risk assessment, even in the presence of overt acquired thrombotic risk factors, physicians should request complete thrombophilia screening for patients with stroke. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPediatric Neurologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords]en_US
dc.titleInherited Thrombophilia in Pediatric Ischemic Stroke: an Egyptian Studyen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume47en_US
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.endpage118en_US
dc.authorid0000-0003-3054-9929-
dc.identifier.wosWOS:000306582900006en_US
dc.identifier.scopus2-s2.0-84863305973en_US
dc.institutionauthorAkar, Mehmet Nejat-
dc.identifier.pmid22759687en_US
dc.identifier.doi10.1016/j.pediatrneurol.2012.05.008-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

8
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

9
checked on Oct 5, 2024

Page view(s)

42
checked on Dec 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.