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https://hdl.handle.net/20.500.11851/6861
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dönmez, Hanife Güler | - |
dc.contributor.author | Çelik, Hasan Tolga | - |
dc.contributor.author | Kayki, Gözdem | - |
dc.contributor.author | Yiğit, Şule | - |
dc.contributor.author | Yurdakök, Murat | - |
dc.contributor.author | Çakar, Ayşe Nur | - |
dc.contributor.author | Beksaç, Mehmet Sinan | - |
dc.date.accessioned | 2021-09-11T15:43:56Z | - |
dc.date.available | 2021-09-11T15:43:56Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 0956-5507 | - |
dc.identifier.issn | 1365-2303 | - |
dc.identifier.uri | https://doi.org/10.1111/cyt.12992 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6861 | - |
dc.description.abstract | Objective To demonstrate the impact of preterm birth on the cytological, cytomorphometrical, and nuclear parameters of neonatal buccal smears. Methods This study consisted of Early Preterm Neonates (EPN; <= 34th gestational week [gw]; n = 36), Late Preterm Neonates (LPN; 34th to <37th gw; n = 46), and Term Neonates (control; >= 37th gw; n = 56). Cytological evaluation and buccal cytome assay were performed using Papanicolaou and Feulgen methods, respectively. Results Cytological evaluation demonstrated that smear background was cleaner (P < .05) and there were less macrophages in the control group (P < .001). Cyto-morphometric analysis showed that the measurements of nuclear diameter, nuclear area, and nucleus-to-cytoplasm ratio were higher in the preterm (EPN and LPN) versus the control groups (P = .016, P < .001, and P < .001, respectively). We also demonstrated that staining intensity of the nucleus and cytoplasm were less intense in the EPN and LPN groups (P < .001). There was no statistically significant difference between the EPN and LPN groups for any parameters (P > .05). Buccal cytome assay showed that nuclear buds were more prevalent in term newborns compared to preterm neonates (P < .001). Conclusions Morphological and cytological properties of neonatal buccal cells are influenced by preterm birth status, and buccal smears may be used as a tool to detect biological markers of neonatal health problems. | en_US |
dc.description.sponsorship | Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [THD-2018--17493] | en_US |
dc.description.sponsorship | This study was funded by Hacettepe University Scientific Research Projects Coordination Unit, Project number: THD-2018--17493. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Cytopathology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | buccal smear | en_US |
dc.subject | cytomorphometry | en_US |
dc.subject | Feulgen | en_US |
dc.subject | micronucleus | en_US |
dc.subject | Papanicolaou | en_US |
dc.subject | preterm birth | en_US |
dc.title | Impact of Preterm Birth on the Cellular Characteristics of Neonatal Buccal Cells | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Basic Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | tr_TR |
dc.authorid | 0000-0001-6362-787X | - |
dc.authorid | 0000-0002-7413-4939 | - |
dc.authorid | 0000-0002-1725-0722 | - |
dc.identifier.wos | WOS:000656465900001 | en_US |
dc.identifier.scopus | 2-s2.0-85107374065 | en_US |
dc.institutionauthor | Çakar, Ayşe Nur | - |
dc.identifier.pmid | 34033163 | en_US |
dc.identifier.doi | 10.1111/cyt.12992 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q2 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 03.14. Department of Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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