Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6848
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dc.contributor.authorAydos, Alp-
dc.contributor.authorGürel, Aykut-
dc.contributor.authorİslakoğlu, Yasemin Öztemur-
dc.contributor.authorNoyan, Senem-
dc.contributor.authorGökçe, Bağdagül-
dc.contributor.authorEcemiş, Tolga-
dc.contributor.authorDedeoğlu, Bala Gür-
dc.date.accessioned2021-09-11T15:43:52Z-
dc.date.available2021-09-11T15:43:52Z-
dc.date.issued2016en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0168875-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6848-
dc.description.abstractPolycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with prevalence of 8-18%. The oocyte within the follicle is surrounded by cumulus cells (CCs), which connect with mural granulosa cells (MGCs) that are responsible for secreting steroid hormones. The main aim of this study is comparing gene expression profiles of MGCs and CCs in PCOS and control samples to identify PCOS-specific differentially expressed genes (DEGs). In this study, two microarray databases were searched for mRNA expression microarray studies performed with CCs and MGCs obtained from PCOS patients and control samples. Three independent studies were selected to be integrated with naive meta-analysis since raw meta-data from these studies were found to be highly correlated. DEGs in these somatic cells were identified for PCOS and control groups. This study enabled us to reveal dysregulation in MAPK (mitogen activated protein kinase), insulin and Wnt signaling pathways between CCs and MGCs in PCOS. The meta analysis results together with qRT-PCR validations provide evidence that molecular signaling is dysregulated through MGCs and CCs in PCOS, which is important for follicle and oocyte maturation and may contribute to the pathogenesis of the syndrome.en_US
dc.description.sponsorshipMedicana International Hospital; HRS Women Hospital; Liv Hospital; TOBB ETU HospitalTOBB Ekonomi ve Teknoloji Universityen_US
dc.description.sponsorshipThe Medicana International Hospital provided support in the form of salaries for the author [BG], HRS Women Hospital provided support in the form of salaries for the authors [AG], [ATA], Liv Hospital provided support in the form of salaries for the author [TE], TOBB ETU Hospital provided support in the form of salaries for the author [CK] but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.en_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleIdentification of Polycystic Ovary Syndrome (pcos) Specific Genes in Cumulus and Mural Granulosa Cellsen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.identifier.volume11en_US
dc.identifier.issue12en_US
dc.authorid0000-0001-6455-3702-
dc.authorid0000-0002-4320-5685-
dc.authorid0000-0002-8670-3393-
dc.authorid0000-0001-7792-7777-
dc.authorid0000-0002-4320-5685-
dc.identifier.wosWOS:000392842900080en_US
dc.identifier.scopus2-s2.0-85006940785en_US
dc.institutionauthorKaya, Cemil-
dc.identifier.pmid27997581en_US
dc.identifier.doi10.1371/journal.pone.0168875-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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