Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/6667
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kayıran, Oğuz | - |
dc.contributor.author | Cüzdan, Suat Sedat | - |
dc.contributor.author | Uysal, Afşin | - |
dc.contributor.author | Koçer, Uğur | - |
dc.date.accessioned | 2021-09-11T15:43:07Z | - |
dc.date.available | 2021-09-11T15:43:07Z | - |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 0971-5916 | - |
dc.identifier.uri | https://doi.org/10.4103/ijmr.IJMR_1428_14 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6667 | - |
dc.description.abstract | Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.relation.ispartof | Indian Journal of Medical Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Ethyl pyruvate | en_US |
dc.subject | ischaemia | en_US |
dc.subject | reperfusion injury | en_US |
dc.subject | skin flap | en_US |
dc.title | Ethyl Pyruvate Improves Skin Flap Survival After Ischaemia Reperfusion Injury | en_US |
dc.type | Article | en_US |
dc.department | Faculties, School of Medicine, Department of Surgical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 146 | en_US |
dc.identifier.startpage | 369 | en_US |
dc.identifier.endpage | 374 | en_US |
dc.identifier.wos | WOS:000423277900012 | en_US |
dc.institutionauthor | Uysal, Afşin | - |
dc.identifier.pmid | 29355144 | en_US |
dc.identifier.doi | 10.4103/ijmr.IJMR_1428_14 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q2 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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