Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6591
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSalman, Hüseyin Enes-
dc.contributor.authorAlser, Maha-
dc.contributor.authorShekhar, Akshay-
dc.contributor.authorGould, Russell A.-
dc.contributor.authorBenslimane, Fatiha M.-
dc.contributor.authorButcher, Jonathan T.-
dc.contributor.authorYalçın, Hüseyin C.-
dc.date.accessioned2021-09-11T15:42:55Z-
dc.date.available2021-09-11T15:42:55Z-
dc.date.issued2021en_US
dc.identifier.citationSalman, H. E., Alser, M., Shekhar, A., Gould, R. A., Benslimane, F. M., Butcher, J. T., & Yalcin, H. C. (2021). Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome. Biomechanics and Modeling in Mechanobiology, 20, 733-750.en_US
dc.identifier.issn1617-7959-
dc.identifier.issn1617-7940-
dc.identifier.urihttps://doi.org/10.1007/s10237-020-01413-5-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6591-
dc.description.abstractCongenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying genetic cause, suggesting that disturbed hemodynamics contribute to the embryonic development of these defects. Left atrial ligation (LAL) is a surgical procedure on embryonic chick resulting in a phenotype resembling clinical HLHS. In this study, we investigated disturbed hemodynamics and deteriorated cardiac growth following LAL to investigate possible mechanobiological mechanisms for the embryonic development of HLHS. We integrated techniques such as echocardiography, micro-CT and computational fluid dynamics (CFD) for these analyses. Specifically, LAL procedure causes an immediate flow disturbance over atrioventricular (AV) cushions. At later stages after the heart septation, it causes hemodynamic disturbances in LV. As a consequence of the LAL procedure, the left-AV canal and LV volume decrease in size, and in the opposite way, the right-AV canal and right ventricle volume increase. According to our CFD analysis, LAL results in an immediate decrease in the left AV canal WSS levels for 3.5-day (HH21) pre-septated hearts. For 7-day post-septated hearts (HH30), LAL leads to further reduction in WSS levels in the left AV canal, and relatively increased WSS levels in the right AV canal. This study demonstrates the critical importance of the disturbed hemodynamics during the heart valve and ventricle development.en_US
dc.description.sponsorshipQatar National Research Fund (QNRF), National Priority Research Program [NPRP 10-0123-170222]; National Science Foundation (NSF), Civil, Mechanical and Manufacturing InnovationNational Science Foundation (NSF)NSF - Directorate for Engineering (ENG) [NSF CMMI 1635712]; Qatar National Libraryen_US
dc.description.sponsorshipThis work was funded by Qatar National Research Fund (QNRF), National Priority Research Program (Grant Number NPRP 10-0123-170222) and National Science Foundation (NSF), Civil, Mechanical and Manufacturing Innovation (Grant Number NSF CMMI 1635712). The publication of this article was funded by the Qatar National Library.en_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofBiomechanics And Modeling In Mechanobiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeft atrial ligationen_US
dc.subjectChick embryoen_US
dc.subjectHypoplastic left heart syndromeen_US
dc.subjectMitral valveen_US
dc.subjectLeft ventricleen_US
dc.subjectShear stressen_US
dc.subjectEmbryonic heart developmenten_US
dc.subjectComputational fluid dynamicsen_US
dc.subjectHemodynamicsen_US
dc.subjectMechanobiologyen_US
dc.titleEffect of Left Atrial Ligation-Driven Altered Inflow Hemodynamics on Embryonic Heart Development: Clues for Prenatal Progression of Hypoplastic Left Heart Syndromeen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümütr_TR
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.startpage733en_US
dc.identifier.endpage750en_US
dc.authorid0000-0002-9168-9987-
dc.identifier.wosWOS:000610040900002en_US
dc.identifier.scopus2-s2.0-85099805881en_US
dc.institutionauthorSalman, Hüseyin Enes-
dc.identifier.pmid33481120en_US
dc.identifier.doi10.1007/s10237-020-01413-5-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

15
checked on Sep 21, 2024

Page view(s)

98
checked on Dec 16, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.