Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/6505
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Butt, A. | - |
dc.contributor.author | Farrukh, A. | - |
dc.contributor.author | Ghaffar, A. | - |
dc.contributor.author | Duran, H. | - |
dc.contributor.author | Oluz, Z. | - |
dc.contributor.author | Rehman, H. ur | - |
dc.contributor.author | Yameen, B. | - |
dc.date.accessioned | 2021-09-11T15:36:59Z | - |
dc.date.available | 2021-09-11T15:36:59Z | - |
dc.date.issued | 2015 | en_US |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://doi.org/10.1039/c5ra10063a | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/6505 | - |
dc.description.abstract | Parasitic nematodes not only cause deadly diseases in plants and animals but also adversely affect agricultural industry and global health, particularly in developing countries. In this study, we planned to combine the concept of enzyme immobilization with nanotechnology to develop magnetic nanoparticles (MNPs) with efficient nematicidal activity in water. A novel nematicidal platform was developed by immobilizing protease (from Streptomyces griseus) on the surface of polymer brush-grafted magnetic nanoparticles (MNPs-PGMA-Pro). For comparison, a monolayer-based nematicidal platform was also developed by functionalizing protease on the surface of glutaraldehyde-functionalized MNPs (MNPs-GA-Pro). MNPs-PGMA-Pro particles show enhanced enzyme activity and stability over a wide range of temperature and pH, as compared to MNPs-GA-Pro. Polymer brush- and monolayer-based protease-functionalized MNPs exhibit superior enzyme activity when compared to the free enzyme. When tested for nematicidal activity against parasitic nematodes (Haemonchus contortus), the polymer brush- based platform retained higher activity over 7 cycles of magnetic separation. The reported platforms can be prospectively employed for water treatment, whereas their reusability over many remediation cycles due to facile magnetic separation promises a substantially reduced treatment cost. | en_US |
dc.description.sponsorship | HEC, PakistanHigher Education Commission of Pakistan [20-1740/RD/10/3368, 20-1799/RD/10-5302]; LUMS start-up grant; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112M804] | en_US |
dc.description.sponsorship | B.Y. acknowledges funding from HEC, Pakistan (Project No. 20-1740/R&D/10/3368 and 20-1799/R&D/10-5302) and LUMS start-up grant. H.D. gratefully acknowledges financial support from TUBITAK (Project No. 112M804). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Soc Chemistry | en_US |
dc.relation.ispartof | Rsc Advances | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | [No Keywords] | en_US |
dc.title | Design of Enzyme-Immobilized Polymer Brush-Grafted Magnetic Nanoparticles for Efficient Nematicidal Activity | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Material Science and Nanotechnology Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 95 | en_US |
dc.identifier.startpage | 77682 | en_US |
dc.identifier.endpage | 77688 | en_US |
dc.authorid | 0000-0002-3794-246X | - |
dc.authorid | 0000-0001-6203-3906 | - |
dc.authorid | 0000-0001-6203-3906 | - |
dc.authorid | 0000-0001-6767-0744 | - |
dc.authorid | 0000-0003-2450-1654 | - |
dc.authorid | 0000-0003-1287-383X | - |
dc.identifier.wos | WOS:000361559900027 | en_US |
dc.identifier.scopus | 2-s2.0-84942034482 | en_US |
dc.institutionauthor | Duran Durmuş, Hatice | - |
dc.identifier.doi | 10.1039/c5ra10063a | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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