Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/5991
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Poyraz, Barış Mustafa | - |
dc.contributor.author | Engin, E. D. | - |
dc.contributor.author | Engin, A. B. | - |
dc.contributor.author | Engin, A. | - |
dc.date.accessioned | 2021-09-11T15:21:16Z | - |
dc.date.available | 2021-09-11T15:21:16Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.uri | https://doi.org/10.1016/j.etap.2021.103657 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/5991 | - |
dc.description.abstract | Diesel exhaust particles (DEP) are the major components of atmospheric particulate matter (PM) and chronic exposure is recognized to enhance respiratory system complications. Although the spread of SARS-CoV-2 was found to be associated with the PMs, the mechanism by which exposure to DEP increases the risk of SARS-CoV-2 infection is still under discussion. However, diesel fine PM (dPM) elevate the probability of SARS-CoV-2 infection, as it coincides with the increase in the number of ACE2 receptors. Expression of ACE2 and its colocalized activator, transmembrane protease serine 2 (TMPRSS2) facilitate the entry of SARS-CoV-2 into the alveolar epithelial cells exposed to dPM. Thus, the coexistence of PM and SARS-CoV-2 in the environment augments inflammation and exacerbates lung damage. Increased TGF-?1 expression due to DEP accompanies the proliferation of the extracellular matrix. In this case, “multifocal ground-glass opacity” (GGO) in a CT scan is an indication of a cytokine storm and severe pneumonia in COVID-19. © 2021 Elsevier B.V. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Environmental Toxicology and Pharmacology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alveolar macrophage | en_US |
dc.subject | Angiotensin-converting enzyme 2 | en_US |
dc.subject | Diesel exhaust particles | en_US |
dc.subject | Ground-glass opacity | en_US |
dc.subject | Severe acute respiratory syndrome corona virus-2 | en_US |
dc.subject | Transforming growth factor-?1 | en_US |
dc.title | The Effect of Environmental Diesel Exhaust Pollution on Sars-Cov Infection: The Mechanism of Pulmonary Ground Glass Opacity | en_US |
dc.type | Review | en_US |
dc.department | Faculties, School of Medicine, Department of Internal Medical Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | tr_TR |
dc.identifier.volume | 86 | en_US |
dc.identifier.wos | WOS:000681066800009 | en_US |
dc.identifier.scopus | 2-s2.0-85104082157 | en_US |
dc.institutionauthor | Poyraz, Barış Mustafa | - |
dc.identifier.pmid | 33838330 | en_US |
dc.identifier.doi | 10.1016/j.etap.2021.103657 | - |
dc.relation.publicationcategory | Diğer | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Review | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 03.14. Department of Internal Medicine | - |
Appears in Collections: | Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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