Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/5880
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tuna, O. | - |
dc.contributor.author | Kuyucak, S. | - |
dc.contributor.author | Baştuğ, T. | - |
dc.date.accessioned | 2021-09-11T15:20:32Z | - |
dc.date.available | 2021-09-11T15:20:32Z | - |
dc.date.issued | 2016 | en_US |
dc.identifier.issn | 2164-6457 | - |
dc.identifier.uri | https://doi.org/10.5890/JAND.2016.03.004 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/5880 | - |
dc.description.abstract | Peptide toxins offer new avenues for development of novel drugs. A- Conotoxin SI, which binds to neuromuscular Nicotinic Acetylcholine Receptor, is such an analgesic drug candidate. Understanding the mechanism of action is crucial for improving the properties of drug candidates. Here, we use docking and molecular dynamics simula- tions to propose a model for binding of A-Conotoxin SI to Nicotinic Acetylcholine Receptor and discuss its paralysis effect. © 2016. L&H Scientific Publishing, LLC. | en_US |
dc.language.iso | en | en_US |
dc.publisher | L and H Scientific Publishing, LLC | en_US |
dc.relation.ispartof | Journal of Applied Nonlinear Dynamics | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Drug discovery | en_US |
dc.subject | Molecular dynamics | en_US |
dc.subject | Potential of mean force | en_US |
dc.subject | Protein-ligand interactions | en_US |
dc.title | Paralysis Mechanism of A-Conotoxin Si From Molecular Dynamics Simulations and Free Energy Calculations | en_US |
dc.type | Article | en_US |
dc.department | Faculties, Faculty of Engineering, Department of Material Science and Nanotechnology Engineering | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü | tr_TR |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 59 | en_US |
dc.identifier.endpage | 64 | en_US |
dc.identifier.scopus | 2-s2.0-85020188694 | en_US |
dc.institutionauthor | Baştuğ, Turgut | - |
dc.identifier.doi | 10.5890/JAND.2016.03.004 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q3 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.6. Department of Material Science and Nanotechnology Engineering | - |
Appears in Collections: | Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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