Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/4136
Title: | Metformin Reduces Ovarian Ischemia Reperfusion Injury in Rats by Improving Oxidative/Nitrosative Stress | Authors: | Demir, Mustafa Yılmaz, Bülent Kalyoncu, Şenol Tuncer, Meltem Bozdağ, Zehra İnce, Onur Bozdayı, Mehmet Akif Ulusal, Hasan Taysi, Seyithan |
Keywords: | Ischemia reperfusion injury Rat ovarian torsion Metformin Oxidative stress index Peroxynitrite |
Publisher: | Elsevier Ltd | Source: | Demir, M., Yilmaz, B., Kalyoncu, S., Tuncer, M., Bozdag, Z., Ince, O., ... & Taysi, S. (2021). Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. Taiwanese Journal of Obstetrics and Gynecology, 60(1), 45-50. | Abstract: | Objective: To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury. Materials and methods: Forty rats were divided equally into five groups; Group 1: sham, Group 2: surgical control with 3-hr torsion and detorsion, Group 3: 50 mg/kg p.o. metformin 30 min before 3-hr torsion, Group 4; metformin just after detorsion, Group 5; metformin 30 min before torsion and just after detorsion. Bilateral ovaries and blood sample were obtained seven days after detorsion for biochemical and histopathological evaluation. Results: Ovarian tissue total anti-oxidant status (TAS) levels were significantly increased in group 4 when compared to group 1, 2 and 3 (all p < 0.01). In addition, there was a significant decrease in tissue oxidative stress index (OSI) level in group 4 with respect to group 2 (p < 0.01). Moreover, serum levels of OSI were significantly higher in group 2 with respect to group 1 and 5 (both p < 0.05). Similarly, there was significant increase in serum levels of peroxynitrite in group 2 as compared to serum levels in group 3 and 5 (p < 0.01 and 0.05, respectively). Furthermore, there were significant decrease in histopathological scores metformin and sham groups when compared to rats in the control group (Group 2). Conclusion: Metformin reduces ischemia reperfusion injury in rat torsion detorsion model by improving histopathological and biochemical findings including TAS, OSI and peroxynitrite. | URI: | https://hdl.handle.net/20.500.11851/4136 https://doi.org/10.1016/j.tjog.2020.10.004 |
ISSN: | 1028-4559 |
Appears in Collections: | Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
WEB OF SCIENCETM
Citations
11
checked on Dec 21, 2024
Page view(s)
84
checked on Dec 16, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.