Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3685
Full metadata record
DC FieldValueLanguage
dc.contributor.authorÖzlü, Büşra-
dc.contributor.authorKabay, Gözde-
dc.contributor.authorBöcek, İlyas-
dc.contributor.authorYılmaz, Merve-
dc.contributor.authorPişkin, Ayşe Kevser-
dc.contributor.authorShim, Bong Sup-
dc.contributor.authorMutlu, Mehmet-
dc.date.accessioned2020-09-17T14:43:37Z-
dc.date.available2020-09-17T14:43:37Z-
dc.date.issued2019-10-30
dc.identifier.citationOzlu, B., Kabay, G., Bocek, I., Yilmaz, M., Piskin, A. K., Shim, B. S., & Mutlu, M. (2019). Controlled release of doxorubicin from polyethylene glycol functionalized melanin nanoparticles for breast cancer therapy: Part I. Production and drug release performance of the melanin nanoparticles. International journal of pharmaceutics, 570, 118613.en_US
dc.identifier.issn0378-5173
dc.identifier.otherarticle number 118613, number of pages 7
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3685-
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2019.118613-
dc.description.abstractIn this study, polyethylene glycol (PEG) conjugated melanin nanoparticles (MNPs) were prepared (PEG-MNPs). A model chemotherapy drug, doxorubicin (DOX), was loaded into the PEG-MNPs with varied concentrations (0.125, 0.250, 0.500 mg/mL). TEM images showed that, DOX-PEG-MNPs are spherical-shaped and 15 ± 2.2 nm in diameter. FTIR spectroscopy analysis demonstrated that MNPs were successfully modified with PEG. The UV–Vis spectroscopy results showed that the drug loading capacity of MNPs was 0.7 mg/ml of DOX in 2 mg/ml of PEG-MNPs. The time course data showed that, the release behavior of DOX from MNPs was primarily diffusion controlled. In vitro cytotoxicity assays demonstrated that MNP and PEG-MNP did not show any toxic effect on mouse fibroblast cells while DOX-PEG-MNP was able to inhibit the proliferation of human breast cancer cells. The results confirm that the application area of MNPs in controlled and prolonged drug release could be extended to the different types of cancer therapeutics.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelanin nanoparticleen_US
dc.subjectNano-sized drug deliveryen_US
dc.subjectControlled releaseen_US
dc.subjectDoxorubicinen_US
dc.subjectBreast canceren_US
dc.titleControlled Release of Doxorubicin From Polyethylene Glycol Functionalized Melanin Nanoparticles for Breast Cancer Therapy: Part I. Production and Drug Release Performance of the Melanin Nanoparticlesen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume570
dc.authorid0000-0001-7146-1937-
dc.identifier.wosWOS:000491033000047en_US
dc.identifier.scopus2-s2.0-85072211461en_US
dc.institutionauthorMutlu, Mehmet-
dc.identifier.pmid31415880en_US
dc.identifier.doi10.1016/j.ijpharm.2019.118613-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.otherNRF-2017; R1A2B4012736
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

10
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

35
checked on Dec 21, 2024

Page view(s)

224
checked on Dec 16, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.