Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3369
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dc.contributor.authorDeveci, Erdem-
dc.contributor.authorKılıç, Alperen-
dc.contributor.authorYılmaz, Onur-
dc.contributor.authorNabi, Aynur-
dc.contributor.authorErgun, Arif Şanlı-
dc.contributor.authorBozkurt, Ayhan-
dc.contributor.authorKurtulmus, Ayşe-
dc.contributor.authorÖztürk, Ahmet-
dc.contributor.authorEşrefoğlu, Mukaddes-
dc.contributor.authorAydın, Mehmet Şerif-
dc.contributor.authorSahan, Ebru-
dc.contributor.authorKırpınar, İsmet-
dc.date.accessioned2020-02-13T07:05:06Z-
dc.date.available2020-02-13T07:05:06Z-
dc.date.issued2019-10
dc.identifier.citationDeveci, E., Kılıç, A., Yılmaz, O., Nabi, A., Ergün, A. S., Bozkurt, A., ... & Şahan, E. (2019). The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats. Psychiatry and Clinical Psychopharmacology, 29(4), 748-759.en_US
dc.identifier.issn24750573
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3369-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/24750573.2019.1631942-
dc.description.abstractBackground: Deep Brain Stimulation (DBS) is the only modality proven to be effective on selective stimulation of the deep brain structures. It was previously reported that, by using DBS, stimulation of nucleus accumbens (NA), a region that plays a pivotal role in the pathogenesis of substance addiction, is effective for the treatment of substance addiction. Objective: The purpose of the current study was to observe how the morphine-conditioned place preference changed in rats by stimulating NA with a non-invasive method, focused ultrasound (US) and to detect whether there would be any tissue damage caused by US waves. Methods: We used low-intensity focused ultrasound (LIFU), a noninvasive modality, in a place conditioning model to stimulate NA in rats. Results: At the initial stage of our study, we used morphine to induce place preference. As expected, morphine administration caused significant place preference. After the place preference was obtained by morphine, we divided the rats into two groups. One group received LIFU waves to NA and the other group received only sham, that is, no stimulation with US waves. Rats in both groups were continued to receive morphine. Then, we investigated whether LIFU and sham will reduce morphine-induced place preference or not. We observed that morphine-induced place preference had an ongoing raise in the sham group while no raise was detected in the ultrasound group. Although LIFU prevented the rats from the raise, it did not cause a significant reduction of morphine preference. Conclusion: We state that there is a need for future studies to investigate the effects of low-intensity focused ultrasound as an alternative treatment modality in addiction.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorphine dependenceen_US
dc.subjectlow intensity focused ultrasounden_US
dc.subjectnucleus accumbensen_US
dc.subjectconditioned place preferenceen_US
dc.subjectdeep brain stimulationen_US
dc.titleThe Effects of Focused Ultrasound Pulsation of Nucleus Accumbens in Opioid-Dependent Ratsen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Electrical and Electronics Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümütr_TR
dc.identifier.volume29
dc.identifier.issue4
dc.identifier.startpage748
dc.identifier.endpage759
dc.relation.tubitak[214S249]en_US
dc.authorid0000-0002-6193-5761-
dc.identifier.wosWOS:000474853800001en_US
dc.identifier.scopus2-s2.0-85068638938en_US
dc.institutionauthorErgun, Arif Şanlı-
dc.identifier.doi10.1080/24750573.2019.1631942-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Elektrik ve Elektronik Mühendisliği Bölümü / Department of Electrical & Electronics Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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