Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3245
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dc.contributor.authorUğur, Kadriye Şerife-
dc.contributor.authorAcar, Muradiye-
dc.contributor.authorÖzol, Duygu-
dc.contributor.authorDağlı, Elif-
dc.contributor.authorÖznur, Murat-
dc.contributor.authorKöşüş, Aydın-
dc.contributor.authorGündüz, Mehmet-
dc.date.accessioned2019-12-30T07:28:06Z
dc.date.available2019-12-30T07:28:06Z
dc.date.issued2019
dc.identifier.citationUgur, K. S., Acar, M., Ozol, D., Dagli, E., Oznur, M., Kosus, A., & Gunduz, M. (2019). Gene Expression Profiles of Tumor Necrosis Factor-? and Endothelin-1 in Obstructive Sleep Apnea. ORL, 81(1), 16-23.en_US
dc.identifier.issn0301-1569
dc.identifier.urihttps://www.karger.com/Article/Pdf/490353-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3245-
dc.description.abstractBackground/Aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-alpha and endothelin (EDN)-1 and obstructive sleep apnea (OSA). Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). There were 63 patients with OSA and 45 patients without OSA. In the OSA group, the median apnea hypopnea index (AHI) was 29.1; in the non-OSA group, the median AHI was 2.1. Blood samples were obtained from all 108 patients for the genetic analysis of the expression of TNF-alpha and EDN-1. PSG findings and gene expression levels were evaluated in both groups. Results: The median (range) age was 46 (20-81) years, BMI 24.9 (15-49), EDN-1 gene expression 0.45 (0.02-67.88) pg/mu L, and TNF-alpha gene expression 1.71 (0.08-59.52) pg/mu L. We found that EDN-1 and TNF-alpha gene expression levels were significantly higher in the OSA group than in the control group (p = 0.009 vs. p < 0.001). Conclusion: EDN-1 and TNF-alpha gene expression levels were associated with the occurrence of OSA. (C) 2018 S. Karger AG, Baselen_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofJournal for Oto-Rhino-Laryngology, Head and Neck Surgeryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectGene expressionen_US
dc.subjectTNF-alphaen_US
dc.subjectEDN-1en_US
dc.subjectPolysomnographyen_US
dc.subjectPOLYMORPHISM; PATHOGENESIS; INFLAMMATION; ASSOCIATIONtr_TR
dc.titleGene Expression Profiles of Tumor Necrosis Factor-Alpha and Endothelin-1 in Obstructive Sleep Apneaen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.identifier.volume81
dc.identifier.issue1
dc.identifier.startpage16
dc.identifier.endpage23
dc.authorid0000-0002-5072-8564-
dc.identifier.wosWOS:000466139900003en_US
dc.identifier.scopus2-s2.0-85058780437en_US
dc.institutionauthorUğur, Kadriye Şerife-
dc.identifier.pmid30537754en_US
dc.identifier.doi10.1159/000490353-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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