Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1860
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dc.contributor.authorUzunoğlu, E.-
dc.contributor.authorYentur, S.-
dc.contributor.authorKayar, A. H.-
dc.contributor.authorTuran, Mustafa-
dc.contributor.authorDönmez, A.-
dc.contributor.authorDireskeneli, G. S.-
dc.contributor.authorErdoğan, N.-
dc.date.accessioned2019-07-10T14:39:32Z
dc.date.available2019-07-10T14:39:32Z
dc.date.issued2017-01
dc.identifier.citationUzunoglu, E., Yentur, S., Kayar, A. H., Turan, M., Donmez, A., Direskeneli, G. S., & Erdogan, N. (2017). Effect of mild heat stress on heat shock protein 70 in a balneotherapy model. European Journal of Integrative Medicine, 9, 86-90. doi:10.1016/j.eujim.2016.11.014en_US
dc.identifier.issn1876-3820
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1860-
dc.description.abstractIntroduction: Fever-induced mild heat stress plays an important role in cellular responses. The best-known heat shock response is heat shock protein (HSP) secretion. We investigated the effect of mild heat stress on serum HSP70 levels and a possible association between the immune system and these molecules by applying a mild heat stress model using a thermal water bath. Method: Peripheral blood samples from 16 osteoarthritis (OA) patients who were treated with 39-40 degrees C thermo-mineral water immersion were examined. Samples were drawn before the first bath, after the first bath, and at the end of treatment. HSP70 levels and interferon-gamma (IFN)-gamma responses in peripheral blood mononuclear cells (PBMC) were evaluated in plasma by enzyme-linked immunosorbent assay ( ELISA) and enzyme-linked immunosorbent spot (ELISPOT) assay, respectively. Results: IFN-gamma-secreting PBMC numbers were increased significantly in response to HSP70, purified protein derivative (PPD), and phytohemagglutinin (PHA) stimulation after the first bath, as compared to before bathing values (p=0.005, p=0.012, p=0.021). HSP level in serum was also increased after the first bath, and decreased to near-baseline levels after treatment, however the differences were not significant. Conclusions: The initial increase in HSP 70 and IFN-gamma levels after the first bath and the final decrease at the end of serial baths suggest that the immune system adapts to the heat stress at the end of this intervention. (C) 2016 Elsevier GmbH. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Inc.en_US
dc.relation.ispartofEuropean Journal of Integrative Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeat shock proteinen_US
dc.subjectThermal wateren_US
dc.subjectOsteoarthritisen_US
dc.subjectBalneotherapyen_US
dc.titleEffect of Mild Heat Stress on Heat Shock Protein 70 in a Balneotherapy Modelen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume9
dc.identifier.issue1
dc.identifier.startpage86
dc.identifier.endpage90
dc.identifier.wosWOS:000396403400012en_US
dc.identifier.scopus2-s2.0-85007495841en_US
dc.institutionauthorTuran, Mustafa-
dc.identifier.doi10.1016/j.eujim.2016.11.014-
dc.authorwosidU-5499-2017-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.otherIstanbul University Scientific Research Unit [213/29042004]en_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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