Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/11716
Title: Dialoxygenation: a Preclinical Trial for Transforming the Artificial Kidney Into an Oxygenator
Authors: Karacanoglu, Dilek
Bedir, Esra
Nakip, Ozlem Saritas
Kesici, Selman
Duran, Hatice
Bayrakci, Benan
Keywords: Dialo-Oxygenation
Extracorporeal Membrane Oxygenation
Continuous Veno-Venous Hemodiafiltration
Artificial Lung
Artificial Kidney
Hydrogen Peroxide
Biomembrane
Oxygenator
Publisher: Lippincott Williams & Wilkins
Abstract: Critically ill patients sometimes require tandem application of extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) which is easier and cheaper. We aimed to transform the kidney membrane into a lung membrane by adding hydrogen peroxide (H2O2) to the dialysate as the oxygen source. A solution containing H2O2 and a dialysate fluid mixture was used as the final dialysate. Starting with 100% H2O2 solution and gradually reducing the volume of H2O2, respectively: 50%, 10%, 5%, 4%, 3%, 2%, and 1%. PRISMAFLEX system, Prismaflex M60 set and a bag of packed red blood cells (pRBCs) were the prototype. blood flow rate was about 40 ml/minute and the dialysis rate was about 200 ml/m2/minute/1.73 m2. blood sampling times were; at the beginning (T0), at 15th (T1), 30th (T2), 60th (T3) minutes. Amongst eight attempts H2O2 concentration that increased the partial oxygen pressure (pO2) level significantly in a reasonable period, without any bubbles, was 3%. Methemoglobinemia was not observed in any trial. After the test with 3%, H2O2 in the dialysate fluid decreased progressively without any H2O2 detection at post-membrane blood. Three percent H2O2 solution is sufficient and safe for oxygenation in CRRT systems. With this new oxy-dialysate solution, both pulmonary and renal replacement can be possible via a single membrane in a simpler manner.
Description: BEDIR, ESRA/0000-0002-7416-0256; karacanoglu, dilek/0009-0001-9062-345X; Duran Durmus, Hatice/0000-0001-6203-3906
URI: https://doi.org/10.1097/MAT.0000000000002260
ISSN: 1058-2916
1538-943X
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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