Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10707
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dc.contributor.authorDemirdoğen, Birsen Can-
dc.contributor.authorÖzturk Başer, Tuğba-
dc.contributor.authorKöylü, Mehmet Talay-
dc.contributor.authorÖzge, Gökhan-
dc.contributor.authorKöz, Özlem Gürbüz-
dc.contributor.authorMumcuoğlu, Tarkan-
dc.date.accessioned2023-10-24T07:01:46Z-
dc.date.available2023-10-24T07:01:46Z-
dc.date.issued2023-
dc.identifier.issn0165-5701-
dc.identifier.issn1573-2630-
dc.identifier.urihttps://doi.org/10.1007/s10792-023-02797-w-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10707-
dc.description.abstractPurposeThe etiology and pathogenesis of pseudoexfoliation syndrome (PEX) and its advancement into pseudoexfoliative glaucoma (PEG) are not fully understood. In this study, we aimed to evaluate the possible role played by two circulating microRNAs (miR-146a-5p and miR-196a-5p) in plasma and their functional genetic variants MIR146A rs2910164 and MIR196A2 rs11614913 in susceptibility to PEG or PEX.MethodsPlasma miRNA relative expression of 27 patients with PEG, 25 patients with PEX and 27 controls was determined using quantitative RT-PCR, and fold change was calculated using the 2(-& UDelta;& UDelta;Ct) method. Genotyping of 300 patients with PEG, 300 patients with PEX, and 300 controls was performed using a PCR-restriction fragment length polymorphism analysis.ResultPlasma miR-146a-5p relative expression was significantly elevated in patients with PEG (3.9-fold) (P < .000) and patients with PEX (2.7-fold) relative to controls (P = .001). The diagnostic ability of plasma miR-146a-5p expression fold change was good for discriminating PEG vs. controls (AUC = 0.897, P < .000), and the optimal decision threshold was 1.83 (sensitivity = 74%, specificity = 93%). Plasma miR-196a-5p relative expression did not differ significantly between study groups. No significant difference in terms of the minor allele frequency or the distribution of genotypes for MIR146A rs2910164 G/C or MIR196A2 rs11614913 C/T was observed between study groups.ConclusionsCirculating miR-146a-5p can contribute to the risk of PEX/PEG. Therefore, we propose that plasma miR-146a-5p can be developed as a potential biomarker for the minimally invasive diagnoses of PEX/PEG and as a potential therapeutic target with further studies.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectMicroRNAen_US
dc.subjectPlasmaen_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.subjectAqueous-Humoren_US
dc.subjectExpressionen_US
dc.subjectCanceren_US
dc.subjectMicrornasen_US
dc.subjectIdentificationen_US
dc.subjectInflammationen_US
dc.subjectPolymorphismen_US
dc.subjectAssociationen_US
dc.subjectDeficiencyen_US
dc.subjectEyesen_US
dc.titleCirculating Mirnas and Their Functional Genetic Variants in Pseudoexfoliative Glaucoma: Potential of Mir-146a as a Diagnostic Biomarkeren_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.authoridkoylu, mehmet talay/0000-0002-7283-3760-
dc.identifier.wosWOS:001023973100003en_US
dc.identifier.scopus2-s2.0-85164198094en_US
dc.institutionauthor-
dc.identifier.pmid37420124en_US
dc.identifier.doi10.1007/s10792-023-02797-w-
dc.authorscopusid56114161500-
dc.authorscopusid58475750900-
dc.authorscopusid56245506300-
dc.authorscopusid35071666600-
dc.authorscopusid23466745400-
dc.authorscopusid23467303700-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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