Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10694
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dc.contributor.authorStojanovic, Jelena-
dc.contributor.authorSavic-Zdravkovic, Dimitrija-
dc.contributor.authorJovanovic, Boris-
dc.contributor.authorVitorovic, Jelena-
dc.contributor.authorBasic, Jelena-
dc.contributor.authorStojanovic, Ivana-
dc.contributor.authorPopovic, Andrea Zabar-
dc.date.accessioned2023-10-24T06:59:14Z-
dc.date.available2023-10-24T06:59:14Z-
dc.date.issued2023-
dc.identifier.issn0048-9697-
dc.identifier.issn1879-1026-
dc.identifier.urihttps://doi.org/10.1016/j.scitotenv.2023.166042-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10694-
dc.description.abstractIn the last few decades, industrial pollution has gained extensive attention in terms of its effect on the aquatic environment. This imposes the need to develop sensitive biomarkers for early detection of pollutant toxicity in ecotoxicological assessment. The advantages of histopathological biomarkers are many, including quick reaction to the presence of contaminants, and the small number of individuals needed for efficient analysis. The present study analyzed the negative effect of lignite coal fly ash (LCFA) and microplastic particles (MPs) on Chironomus riparius, a suggested model organism by the Organization for Economic Cooperation and Development (OECD). This study aimed to perform histological analyses of larval tissues and target potential changes in treated groups that could serve as promising histopathological biomarkers of the contaminant's negative effects. Following that, other known sensitive sub-organismal biomarkers were analyzed and paired with the histopathological ones. Histological analysis of larvae showed a significantly decreased length of microvilli in midgut regions II and III in both treatments. Treatments with MPs affected oxidative stress parameters: thiobarbituric acid reactive sub-stances (TBARS), advanced oxidation protein products (AOPP), superoxide dismutase (SOD), and hemoglobin levels, while LCFA significantly affected all tested sub-organismal biomarkers (DNA damage, levels of AOPP, SOD, and hemoglobin), except catalase (CAT) and TBARS. When observing histological slides, a significant shortage of brush border length in the posterior parts of the midgut was detected in all treatments. In the case of LCFA, the appearance of intensive vacuolization of digestive cells with inclusions resembling apoptotic bodies, in mentioned regions was also detected. This study demonstrated high sensitivity of brush border length to the MPs and LCFA exposure, complementary to other tested sub-organismal biomarkers. Revealing the great potential of this histopathological biomarker in ecotoxicological studies contributes to the international standard ecotoxi-cology assessment of emerging pollutants.en_US
dc.description.sponsorshipEuropean Commission [101072777]; Serbian Ministry of Science, Technological Development and Innovation, Republic of Serbia [451-03-47/2023-01/200124, 451-03-47/2023-01/200007]; Marie Curie Actions (MSCA) [101072777] Funding Source: Marie Curie Actions (MSCA)en_US
dc.description.sponsorshipThis research was supported by the European Commission-HORI-ZON-MSCA-2021-DN-01, Grant no. 101072777, Integrated Cross-Sectoral Solutions to Micro-and Nanoplastic Pollution in Soil and Groundwater Ecosystems - Plastic Underground. This study was supported by the Serbian Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grant no. 451-03-47/2023-01/200124 and Grant no. 451-03-47/2023-01/200007.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofScience of The Total Environmenten_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistologyen_US
dc.subjectChironomidaeen_US
dc.subjectBiomarkersen_US
dc.subjectMicroplasticsen_US
dc.subjectFly ashen_US
dc.subjectOxidative Stressen_US
dc.subjectRiparius Dipteraen_US
dc.subjectFresh-Wateren_US
dc.subjectCoal Ashen_US
dc.subjectFishen_US
dc.subjectContaminantsen_US
dc.subjectHemoglobinen_US
dc.subjectToxicityen_US
dc.subjectLeachateen_US
dc.subjectCopperen_US
dc.titleHistopathology of Chironomids Exposed To Fly Ash and Microplastics as a New Biomarker of Ecotoxicological Assessmenten_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume903en_US
dc.authoridSavic Zdravkovic, Dimitrija/0000-0002-3134-0230-
dc.authoridStojanovic, Jelena/0000-0002-7217-4793-
dc.identifier.wosWOS:001063253100001en_US
dc.identifier.scopus2-s2.0-85167786036en_US
dc.institutionauthor-
dc.identifier.pmid37543338en_US
dc.identifier.doi10.1016/j.scitotenv.2023.166042-
dc.authorscopusid8712359300-
dc.authorscopusid57203856614-
dc.authorscopusid36598601000-
dc.authorscopusid57205692731-
dc.authorscopusid18233282800-
dc.authorscopusid7003552917-
dc.authorscopusid58339719900-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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