Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10502
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dc.contributor.authorÖzçatal, Y.-
dc.contributor.authorAkat, F.-
dc.contributor.authorTatar, Y.-
dc.contributor.authorFıçıcılar, H.-
dc.contributor.authorSerdaroğlu, B.-
dc.contributor.authorTopal, Çelikkan, F.-
dc.contributor.authorBaştuğ, M.-
dc.date.accessioned2023-07-14T20:18:06Z-
dc.date.available2023-07-14T20:18:06Z-
dc.date.issued2023-
dc.identifier.issn1043-4666-
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2023.156279-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10502-
dc.description.abstractPurpose: Diabetes is a metabolic disorder characterized by chronic hyperglycemia due to insulin deficiency and/or loss of its action. Diabetic myopathy causes functional limitations in diabetic patients. The beneficial effects of high-intensity interval training (HIIT) are widely reported. We have hypothesized that HIIT application would prevent the development of diabetic myopathy. Methods: Male, Wistar albino rats (10 W) were randomly divided into four groups (1)Control(C), (2)Diabetes(DM), (3)Training(HIIT), and (4)Diabetes + Training(DM + HIIT). Streptozotocin(60 mg/kg) was injected for the induction of diabetes. The maximum exercise capacity(MEC) of animals was determined by an incremental load test. HIIT protocol (4 min 85–95 % MEC, 2 min 40–50 % MEC, 6 cycles, 5 days/week) was applied for 8 weeks. In the end, functional parameters, atrophy, and resistance to fatigue in soleus and EDL muscles were evaluated. IL-6, FNDC5, and myonectin levels were measured in EDL, soleus, and serum. Results: We observed atrophy, fatigue sensitivity, and proinflammatory alterations (IL-6 increase) in the EDL samples due to diabetic myopathy which were not observed in the soleus samples. HIIT application prevented the aforementioned detrimental alterations. Both force-frequency response and parallelly the twitch amplitude increased significantly in the DM + HIIT group. Half relaxation time (DT50) increased in both exercising and sedentary diabetics. FNDC5 was significantly higher in the exercising animals in soleus samples. Myonectin was significantly higher in the soleus muscle only in the DM + HIIT group. Conclusion: Current findings show that diabetic myopathy develops earlier in glycolytic-fast-twitch fibers(EDL) than in oxidative-slow-twitch fibers(soleus). Furthermore, HIIT application prevents atrophy in skeletal muscle, increases resistance to fatigue, and has an anti-inflammatory effect. New findings: The current study analyzes the myokine profile and skeletal muscle function under the effect of diabetes HIIT-type exercise. We also measured maximal exercise capacity and tailored the exercise program individually according to the result. Diabetic myopathy is an important complication of diabetes yet still, it is not understood completely. Our results show that HIIT-type training would be beneficial in diabetic myopathy but further investigation is needed to understand the whole molecular mechanism. © 2023 Elsevier Ltden_US
dc.description.sponsorship21B0230016en_US
dc.description.sponsorshipThis study was funded by AU BAP (21B0230016) and presented as oral communication in 47. National Physiology Congress, Antalya, Turkey. We would like to express our gratitude to Dr. Ahmet Mert ERTUNÇ for sharing his methodological information with us.en_US
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.relation.ispartofCytokineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic myopathyen_US
dc.subjectHIITen_US
dc.subjectIsolated skeletal muscleen_US
dc.subjectMyokineen_US
dc.titleEffects of High-Intensity Interval Training (hiit) on Skeletal Muscle Atrophy, Function, and Myokine Profile in Diabetic Myopathyen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume169en_US
dc.identifier.wosWOS:001024031400001en_US
dc.identifier.scopus2-s2.0-85162082339en_US
dc.institutionauthor-
dc.identifier.doi10.1016/j.cyto.2023.156279-
dc.authorscopusid58316569800-
dc.authorscopusid57191866333-
dc.authorscopusid57210943925-
dc.authorscopusid6602677387-
dc.authorscopusid58316139500-
dc.authorscopusid57216963484-
dc.authorscopusid6506192760-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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