Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/10395
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Açıkgöz, H.N. | - |
dc.contributor.author | Karaman, A. | - |
dc.contributor.author | Şahin, M.A. | - |
dc.contributor.author | Çaylan, Ö.R. | - |
dc.contributor.author | Büke, G.C. | - |
dc.contributor.author | Yıldırım, E. | - |
dc.contributor.author | Eroğlu, İ.C. | - |
dc.date.accessioned | 2023-04-16T10:02:13Z | - |
dc.date.available | 2023-04-16T10:02:13Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0041-624X | - |
dc.identifier.uri | https://doi.org/10.1016/j.ultras.2022.106911 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/10395 | - |
dc.description.abstract | In the present study, the capabilities of different chip materials for acoustic particle manipulation have been assessed with the same microfluidic device architecture, under the same actuator and flow conditions. Silicon, glass, epoxy with fiberglass filling (FR4), polydimethylsiloxane (PDMS) and polymethyl methacrylate (PMMA) are considered as chip materials. The acoustophoretic chips in this study were manufactured with four different fabrication methods: plasma etching, chemical etching, micromachining and molding. A novel chip material, FR4, has been employed as a microfluidic chip material in acoustophoretic particle manipulation for the first time in literature, which combines the ease of manufacturing of polymer materials with improved acoustic performance. The acoustic particle manipulation performance is evaluated through acoustophoretic focusing experiments with 2μm and 12μm polystyrene microspheres and cultured breast cancer cell line (MDA-MB-231). Unlike the common approach in the literature, the piezoelectric materials were actuated with partitioned cross-polarized electrodes which allowed effective actuation of different family of chip materials. Different from previous studies, this study evaluates the performance of each acoustophoretic device through the perspective of synchronization of electrical, vibrational and acoustical resonances, considers the thermal performance of the chip materials with their effects on cell viability as well as manufacturability and scalability of their fabrication methods. We believe our study is an essential work towards the commercialization of acoustophoretic devices since it brings a critical understanding of the effect of chip material on device performance as well as the cost of achieving that performance. © 2022 Elsevier B.V. | en_US |
dc.description.sponsorship | 115M684, 118E023, 220M010 | en_US |
dc.description.sponsorship | The production and design of the polymer and glass chips is supported by the Turkish Scientific and Technical Research Council , under Grant No. 115M684 . The production and design of the silicon chips is supported by the Turkish Scientific and Technical Research Council , under Grant No. No. 118E023 . The biological studies in this work are supported by the Turkish Scientific and Technical Research Council under Grant No. 220M010 . The technical support from Mr. Cem Orhun in piezoelectric actuator development is greatly appreciated. Cell and particle imaging support from Dr. Altuğ Özçelikkale, Mr. Ali Aykut Akalın and Mr. Barış Dedekargınoğlu is greatly appreciated. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Ultrasonics | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acoustofluidics | en_US |
dc.subject | Cultured cancer cells | en_US |
dc.subject | FR4 | en_US |
dc.subject | Piezoelectric actuators | en_US |
dc.subject | Ultrasonics | en_US |
dc.subject | Vibrations | en_US |
dc.subject | Acoustic waves | en_US |
dc.subject | Cancer cells | en_US |
dc.subject | Cell culture | en_US |
dc.subject | Cells | en_US |
dc.subject | Diseases | en_US |
dc.subject | Fluidic devices | en_US |
dc.subject | Glass | en_US |
dc.subject | Microchannels | en_US |
dc.subject | Microfluidics | en_US |
dc.subject | Molecular biology | en_US |
dc.subject | Piezoelectric actuators | en_US |
dc.subject | Piezoelectricity | en_US |
dc.subject | Polymethyl methacrylates | en_US |
dc.subject | Polystyrenes | en_US |
dc.subject | Silicon | en_US |
dc.subject | Silicones | en_US |
dc.subject | Acoustic particle manipulations | en_US |
dc.subject | Acoustofluidic | en_US |
dc.subject | Cancer cells | en_US |
dc.subject | Cell manipulation | en_US |
dc.subject | Cultured cancer cell | en_US |
dc.subject | Fabrication method | en_US |
dc.subject | FR4 | en_US |
dc.subject | Performance | en_US |
dc.subject | Silicon glass | en_US |
dc.subject | Vibration | en_US |
dc.subject | Polydimethylsiloxane | en_US |
dc.subject | baysilon | en_US |
dc.subject | dimeticone | en_US |
dc.subject | poly(methyl methacrylate) | en_US |
dc.subject | silicon | en_US |
dc.subject | acoustics | en_US |
dc.subject | microfluidics | en_US |
dc.subject | Acoustics | en_US |
dc.subject | Dimethylpolysiloxanes | en_US |
dc.subject | Microfluidics | en_US |
dc.subject | Polymethyl Methacrylate | en_US |
dc.subject | Silicon | en_US |
dc.title | Assessment of Silicon, Glass, Fr4, Pdms and Pmma as a Chip Material for Acoustic Particle/Cell Manipulation in Microfluidics | en_US |
dc.type | Article | en_US |
dc.department | TOBB ETÜ | en_US |
dc.identifier.volume | 129 | en_US |
dc.identifier.scopus | 2-s2.0-85144358472 | en_US |
dc.institutionauthor | … | - |
dc.identifier.pmid | 36528906 | en_US |
dc.identifier.doi | 10.1016/j.ultras.2022.106911 | - |
dc.authorscopusid | 57735702200 | - |
dc.authorscopusid | 57736527800 | - |
dc.authorscopusid | 57212340089 | - |
dc.authorscopusid | 57217485587 | - |
dc.authorscopusid | 57195074303 | - |
dc.authorscopusid | 36165070100 | - |
dc.authorscopusid | 57736029300 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
CORE Recommender
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.