Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/10366
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gür Maz, Tuğçe | - |
dc.contributor.author | Çalışkan, Huseyin Burak | - |
dc.date.accessioned | 2023-04-16T10:01:18Z | - |
dc.date.available | 2023-04-16T10:01:18Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1307-6175 | - |
dc.identifier.uri | https://doi.org/10.25135/acg.oc.145.2302.2705 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/10366 | - |
dc.description.abstract | Inhibition of soluble epoxide hydrolase (sEH) is implicated as a new therapeutic approach against inflammatory disorders in the context of metabolic and cardiovascular diseases. In the course of our ongoing research on sEH inhibitors, we synthesized novel piperidine/piperazine amide derivatives of the chromone-2-carboxylic acid, and evaluated their inhibitory properties against human sEH. The chemical structures of the target compounds (2-5, 79) were elucidated by means of 1H-NMR, 13C-NMR and HRMS spectra. Initial screening of final compounds against sEH at a final concentration of 10 .M led to the identification of compound 7, which inhibited sEH activity in a concentration-dependent manner with an IC50 = 1.75 .M. Therefore, this chromone-2-amide derivative 7 decorated with benzyl piperidine on the amide side can be regarded as a novel lead structure, which pave the way of developing new analogues with improved inhibitory activities against sEH. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Acg Publications | en_US |
dc.relation.ispartof | Organic Communications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Fluorometric | en_US |
dc.subject | inhibition | en_US |
dc.subject | piperazine | en_US |
dc.subject | piperidine | en_US |
dc.subject | soluble epoxide hydrolase | en_US |
dc.subject | ?2023 ACG Publication | en_US |
dc.subject | All right reserved | en_US |
dc.subject | Insights | en_US |
dc.subject | Target | en_US |
dc.title | Synthesis of Some Piperazine/Piperidine Amides of Chromone-2 Carboxylic Acid as Potential Soluble Epoxide Hydrolase (seh) Inhibitors | en_US |
dc.type | Article | en_US |
dc.department | TOBB ETÜ | en_US |
dc.authorid | gur maz, tugce/0000-0001-8916-2492 | - |
dc.identifier.wos | WOS:000948356000001 | en_US |
dc.identifier.scopus | 2-s2.0-85163122954 | en_US |
dc.institutionauthor | … | - |
dc.identifier.doi | 10.25135/acg.oc.145.2302.2705 | - |
dc.authorwosid | gur maz, tugce/AAC-4388-2019 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q4 | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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