Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10362
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dc.contributor.authorKafa, Barış-
dc.contributor.authorÇakmak, Gökhan-
dc.contributor.authorSahin, Mehmet Şükrü-
dc.contributor.authorHelvacıoğlu, Fatma-
dc.contributor.authorFidan, Pınar Ayran-
dc.contributor.authorDemir, Teyfik-
dc.contributor.authorYazıcı Güvercin, Ayşe Canan-
dc.date.accessioned2023-04-16T10:01:18Z-
dc.date.available2023-04-16T10:01:18Z-
dc.date.issued2023-
dc.identifier.issn0363-5465-
dc.identifier.issn1552-3365-
dc.identifier.urihttps://doi.org/10.1177/03635465231153640-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10362-
dc.description.abstractBackground: Peritendinous injection of local anesthetics, alone or in combination with corticosteroids, is widely used in the treatment of tendinopathies. Toxicity of local anesthetics has been demonstrated in many cells, including myocytes, chondrocytes, and neurons. Bupivacaine and lidocaine are known to have time- and dose-dependent cytotoxicity in these cells. The effects of these agents on the tendon remain unknown. Purpose: To show histological and biomechanical effects after the injection of different local anesthetics and steroids, both single and combined, at different concentrations into the peritendinous sheath of rat Achilles tendon. Study Design: Controlled laboratory study. Methods: In the study, 100 rats were divided into 10 groups with equal body weights. Inflammation was induced in both Achilles tendons of each rat by means of the ball drop technique; 7 hours later, injections were made into the peritendinous sheaths of both Achilles tendons using lidocaine, bupivacaine, and dexamethasone as appropriate for the rat's group. At the end of the first week, the right Achilles tendons of the rats were removed for histological study. Left Achilles tendons were evaluated in terms of biomechanics. Results: Histological findings demonstrated that the group with the most toxicity to the tendon was the group that received injection of dexamethasone alone. The groups with the least toxicity were those receiving dexamethasone combined with low- or high-dose bupivacaine. Biomechanical findings showed that the experimental groups had similar results to each other with the exception of the groups receiving 0.25% bupivacaine alone and dexamethasone alone, in which tendons revealed higher tensile strength. Conclusion: Local anesthetic and steroid applications have different histological and biomechanical effects on the tendon. Although the dexamethasone-injected group was the most affected in terms of histology, these changes could not be demonstrated biomechanically.en_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAmerican Journal of Sports Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchilles tendonen_US
dc.subjectbiomechanics of tendonen_US
dc.subjecthistological labelingen_US
dc.subjectlocal anestheticsen_US
dc.subjectsteroidsen_US
dc.subjecttendonen_US
dc.subjectMechanical-Propertiesen_US
dc.subjectBupivacaineen_US
dc.subjectInjectionsen_US
dc.subjectDexamethasoneen_US
dc.subjectTendinopathyen_US
dc.subjectRopivacaineen_US
dc.subjectLidocaineen_US
dc.subjectTenocytesen_US
dc.subjectToxicityen_US
dc.subjectRupturesen_US
dc.titleHistological and Biomechanical Effects of Local Anesthetics and Steroids on Achilles Tendon: a Study in Ratsen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.authoridFidan, Pınar Ayran/0000-0003-3047-0305-
dc.authoridKafa, Baris/0000-0003-4548-534X-
dc.identifier.wosWOS:000937525200001en_US
dc.identifier.scopus2-s2.0-85148740504en_US
dc.institutionauthor-
dc.identifier.pmid36815784en_US
dc.identifier.doi10.1177/03635465231153640-
dc.authorwosidFidan, Pınar Ayran/ABG-5365-2020-
dc.authorscopusid57035297400-
dc.authorscopusid24474010600-
dc.authorscopusid36337954400-
dc.authorscopusid24471309500-
dc.authorscopusid57200368091-
dc.authorscopusid23488228600-
dc.authorscopusid58170387800-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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