Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10328
Title: Effects of Simultaneous Versus Post Exposure Epigallocatechin-3 Treatment on Aluminum Induced Neurotoxicity in Rat Hippocampus: a Multi-Approach Study
Authors: Palabıyık-Yücelik, Şaziye Sezin
Zeybek, Naciye Dilara
Çınar, İrfan
Akpınar, Erol
Zırh, Elham Bahador
Sipahi, Hande
Halıcı, Zekai
Keywords: Aluminum
Neurotoxicity
Epigallocatechin gallate
NMDAR
Nitric-Oxide
Acetylcholinesterase Activity
Inhibition
Expression
Diseases
Stress
Assay
Acid
Publisher: Elsevier
Abstract: Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-Daspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a wellknown antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were downregulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al.
URI: https://doi.org/10.1016/j.etap.2023.104061
https://hdl.handle.net/20.500.11851/10328
ISSN: 1382-6689
1872-7077
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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