Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10322
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dc.contributor.authorDemirdogen, Birsen Can-
dc.contributor.authorKilic, Osman Oguzhan-
dc.contributor.authorYılmaz, Ata Ayhan-
dc.contributor.authorMungan, Semra-
dc.contributor.authorNeselioglu, Salim-
dc.contributor.authorErel, Özcan-
dc.date.accessioned2023-04-16T10:00:17Z-
dc.date.available2023-04-16T10:00:17Z-
dc.date.issued2023-
dc.identifier.issn0360-4012-
dc.identifier.issn1097-4547-
dc.identifier.urihttps://doi.org/10.1002/jnr.25163-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10322-
dc.description.abstractThis study aimed to assess the possible association between cognitive impairment and two important biochemical biomarkers of oxidative stress, thiol-disulfide homeostasis (TDH), and ischemia-modified albumin (IMA) in patients with multiple sclerosis (MS). This study included 85 patients with MS (38 treatment-naive relapsing-remitting MS (RRMS), 31 RRMS on fingolimod therapy, and 16 secondary progressive MS (SPMS)) and 33 healthy controls. Cognitive evaluation was carried out by applying the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) test battery and the scores were adjusted for age and years of education. Plasma TDH was assessed using an automated method and plasma IMA levels were determined using the cobalt-albumin binding assay. Plasma native thiol and total thiol levels were significantly decreased in patients with SPMS when compared with the naive patients and healthy controls. Cognitive impairment was detected in 47.4% of naive patients, 64.5% of patients on fingolimod therapy, and 80% of patients with SPMS. Naive patients or patients on fingolimod therapy who were cognitively impaired had significantly decreased levels of native thiol and total thiol compared to the cognitively normal patients. Logistic regression analysis revealed total thiol and native thiol to be significantly associated with cognitive impairment in naive patients and patients on fingolimod therapy. Significant correlations were determined between BICAMS scores, TDH, IMA, clinical indices of disease severity (EDSS and MSSS), and magnetic resonance imaging parameters. This study has shown for the first time that plasma TDH parameters are associated with cognitive impairment in MS.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBICAMSen_US
dc.subjectbiomarkeren_US
dc.subjectBrief Visuospatial Memory Testen_US
dc.subjectCalifornia Verbal Learning Testen_US
dc.subjectEDSSen_US
dc.subjectMSSSen_US
dc.subjectoxidative stressen_US
dc.subjectSymbol Digit Modalities Testen_US
dc.subjectInternational Cognitive Assessmenten_US
dc.subjectOxidative Stressen_US
dc.subjectMinimal Assessmenten_US
dc.subjectFingolimoden_US
dc.subjectValidationen_US
dc.subjectBiomarkersen_US
dc.subjectDisabilityen_US
dc.subjectDiagnosisen_US
dc.subjectDamageen_US
dc.subjectAssayen_US
dc.titleNeurocognitive Impairment in Multiple Sclerosis and Its Association With Thiol-Disulfide Homeostasis and Ischemia-Modified Albuminen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume101en_US
dc.identifier.issue4en_US
dc.identifier.startpage508en_US
dc.identifier.endpage523en_US
dc.authoridMungan, Semra/0000-0002-6469-5185-
dc.authoridYilmaz, Ata Ayhan/0000-0001-6339-8181-
dc.authoridEREL, Ozcan/0000-0002-2996-3236-
dc.authoridKilic, Osman Oguzhan/0000-0003-4779-8390-
dc.identifier.wosWOS:000907587900001en_US
dc.identifier.scopus2-s2.0-85145669502en_US
dc.institutionauthor-
dc.identifier.pmid36602284en_US
dc.identifier.doi10.1002/jnr.25163-
dc.authorwosidMungan, Semra/AAR-3500-2021-
dc.authorscopusid56114161500-
dc.authorscopusid57204432455-
dc.authorscopusid58025047500-
dc.authorscopusid35722606900-
dc.authorscopusid36642946400-
dc.authorscopusid7003566828-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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